Slowdown in the rate of cell division of cancer gene therapy may

The biggest difference between cancer cells and normal cells is split rate. A normal cell to receive split signals, often activation of a "slowdown" (anterior system), to halt cell division. back quiescent cells. Deceleration mistakes will lead to uncontrolled cell division and cell growth. Weizmann Institute researchers to study this deceleration systems, to identify a group of related genes. Details published in the February 25 Internet edition of "Nature Genetics>. The results showed that these genes will lead to abnormal activity of many types of cancer. This finding can be restored in future contribute to the development of drugs out of cells slowdown gates to stop the deterioration of cancer. First, the researchers split the order was received to map out normal cells activated gene network. "Splittist" extracellular signal is the growth factor, initiating a series of events within the cell, eventually producing protein. Some proteins trigger cell division, while others installed slowdown cell division protein for Gates. To find the key gene, the researchers examined a large number of genes and their activity data. Weizmann researchers discovered to their amazement that received growth factor signal, the cell is not to remain brisk. Gene different periods of opening and closing conditions. Active at first, a small increase in gene expression, sustained 20-40 minutes, these genes cause cell division. In contrast, in 40-240 minutes after the second signal to reach the fifth active. Expression of the gene responsible for the termination of active cell division. Subsequent research will focus on identifying the active period of four active genes. proven time and the installation of an active gene for the slowdown of cell division Gates. Found 50 active genes will hinder the first genetic activity. Most of this deceleration systems directly attached to the cell division protein genes prevent these genes function. there is a biodegradable protein messenger RNA carrying the protein coding cell division. Researchers sources of cancer in patients with ovarian cancer were detected findings, the "slowdown" gene activity. there is a correlation between survival and aggressive disease, which was found to provide for the development of individualized treatment for cancer in the right direction. The future to identify the various types of cancer caused the precise factors beyond the control of cell division, termination of the research and development of effective prevention and treatment programs for the growth of tumor new clues.