The new protein was identified with lung cancer

In the United States, lung cancer is the leading cause of cancer deaths in the first. Researchers have discovered a new set of proteins in lung cancer may play an important role in the development process. This protein can destroy an important tumor suppressor gene p53. These studies will be published in November 17, 2004 in the Journal of the Nati onal Cancer Institute there. In the entire genome, p53 tumor suppressor gene may be the most powerful. P53 in normal working hours, it can adjust a number of important cellular processes, including cell growth and death. DNA repair and angiogenesis. Research shows that at least half of the cancer that took place in the p53 mutation. In the new study, Ohio University researchers found that when a protein called Pirh2 expression will inhibit the activity of p53 . Villalona and his colleagues to investigate the human and mouse lung samples Pirh2 expression , revealed that exists between Pirh2 and the development of cancer links. They found that Pirh2 expression in human lung cancer and 93% of the 84 mice in the tumor tissue than in normal water to a high level. When Pirh2 expression, it will be like the ubiquitin-like adhesive to glue on the p53 protein. Because ubiquitin function is necessary to destroy proteins were labeled, So the damage weakens the proteins p53 and opens the door to the worsening of cancer. The researchers found lung cancer in mice of p53 was "ubiquitin" level is far higher than the normal level. and the expression level of p53 in tumor tissue are relatively low. However, another analysis showed Pirh2 expression of the p53 mutation, but simply to make it function. This research study provides a possible interference targets. Researchers point out the current market has been the disintegration of the protein drug for sale. These drugs may be able to counter Pirh2 by restoring p53 function of the carcinogenic effect. At present, however, requires further research.