The pathological features of large cell lung cancer

World Health Organization (WHO) in four types of lung pathology were squamous cell carcinoma and adenocarcinoma. small cell undifferentiated carcinoma and large cell undifferentiated carcinoma. Clinicians familiar with the first three types of pathology. However, large cell undifferentiated carcinoma of the lung (lung cancer cells) are relatively unfamiliar with the low rate of clinical diagnosis. The first large-cell lung cancer is characterized by fiberoptic bronchoscopy and sputum cytology, the positive biopsy rate low often difficult to determine before surgery pathology, diagnosis and preoperative and postoperative pathologic diagnosis often do not meet. In group, a summary, a total of 74 patients, diagnosed before without exception; Another hospital reported 41 cases of fiberoptic bronchoscopy, only one large cell lung cancer were diagnosed. Jiu reasons, and the origin of large cell lung cancer is very complex relationship. By definition, light microscopic examination of large cell lung cancer two to three times greater than common cancer, there are two subtypes : First, large cell carcinoma. Second, clear cell carcinomas, often for a variety of mixed origin of cancer, tumor part of squamous differentiation in the electron microscope. part of tumor differentiation, often misdiagnosed as a poorly differentiated adenocarcinoma or squamous cell carcinoma. Sometimes on the same specimens both squamous differentiation as well as glandular differentiation, but there is no characteristic ultrastructure However, the characteristics of neuroendocrine tumors, some large cell lung cancer pathologists regard to the ownership of neuroendocrine tumors. Therefore patients should submit suspicious piece of a larger organization, and immunohistochemistry and electron microscopy to increase the accuracy of diagnosis. A second feature of large cell lung cancer is found in male heavy smoker, a huge mass lesions with peripheral prevalent. Domestic and reporting of data, the sex ratio was 10:1 for the highest and the lowest 3:1,60% above a heavy smoking history. The radiographic inspection, the peripheral lung lesion, accounting for more than 80%. mass density of the shadow of the block, no cavities, less rules around the tumor, but a huge mass. The average diameter of 8 centimeters above, accompanied mediastinal lymph node metastasis. A center lesions, all accompanied obstructive pneumonia or pulmonary atelectasis. smaller peripheral lung lesions radiology appear to be patchy shadow or real change nodules. Doctors in the face of a huge mass of peripheral lung cancer, to raise awareness of the large cell lung cancer, particularly lung lesions on the leaves. A third characteristic of large cell lung cancer incidence rate is low, the degree of malignancy, poor treatment, the prognosis is poor. Comparing with squamous cell carcinoma, adenocarcinoma and small cell lung cancer. The incidence of lung cancer cell lung cancer 0.5%-5.0% about the higher incidence of autopsy specimens. However, compared with other types of pathology, and lower incidence rate. In large cell lung cancer clinical neuroendocrine tumors are highly malignant, fast-growing, and sometimes a "weather" Early lymphatic and hematogenous metastasis appeared. Although surgical resection, radiotherapy, chemotherapy, the five-year survival rate is below 25%, due to a failure of local recurrence and distant metastasis. or both. But the main reason is distant metastasis, about 80% of the patients developed pulmonary, pleural, brain, bone, liver and other organs, lead to treatment failure. At present, large-cell lung cancer were treated in an integrated, simple surgical treatment worse before it, Postoperative radiotherapy and chemotherapy are also exploring. Phase IV has been a patient for treatment or surgical excision is not complete, after a transfer of patients relapse. chemotherapy or radiation therapy should be made. Limited because of large-cell lung cancer, chemotherapy drugs, or what the best treatment plan, pending further clinical study.